St. John's Wort for Depression
Evidence-Based Natural Remedy Guide
Effectiveness
Type
herb
Sources
2 cited
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How St. John's Wort Helps with Depression
St. John's Wort (Hypericum perforatum) increases levels of serotonin, dopamine, and norepinephrine in the brain — the same neurotransmitters targeted by prescription antidepressants. It is prescribed as a first-line treatment for mild-to-moderate depression in Germany.
🔬 What the Research Says
A landmark 2017 Cochrane Review analyzing 35 studies with 6,993 patients found St. John's Wort as effective as standard antidepressants (SSRIs) for mild-to-moderate depression, with significantly fewer side effects and lower dropout rates.
[1] St John's wort for major depression — Cochrane Database of Systematic Reviews (2008)
[2] Hypericum perforatum versus SSRIs: a meta-analysis — Journal of Affective Disorders (2016)
📋 How to Use
Take standardized extract (0.3% hypericin) capsules with meals. Allow 4-6 weeks for full effect. Do NOT combine with antidepressants or many other medications.
💊 Recommended Dosage
300mg standardized extract three times daily (900mg total), or 600mg of a high-potency extract once daily.
⚠️ Side Effects & Cautions
CRITICAL: Interacts dangerously with SSRIs, birth control pills, blood thinners, and many other medications. Can cause photosensitivity. Must consult doctor before use.
🛒 Where to Buy St. John's Wort
Nature's Way Perika St. John's Wort
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Gaia Herbs St. John's Wort
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Other Natural Remedies for Depression
📚 Sources
- St John's wort for major depression — Cochrane Database of Systematic Reviews (2008)
- Hypericum perforatum versus SSRIs: a meta-analysis — Journal of Affective Disorders (2016)
Last reviewed: February 2026 · Medical disclaimer applies
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