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Cayenne Pepper for Inflammation

Evidence-Based Natural Remedy Guide

Effectiveness

★★★★★

Type

food

Sources

1 cited

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How Cayenne Pepper Helps with Inflammation

Capsaicin depletes substance P (a pain and inflammation signaling molecule) and activates TRPV1 receptors that modulate the inflammatory response.

🔬 What the Research Says

A Cochrane review confirmed topical capsaicin's anti-inflammatory and analgesic effects for chronic pain conditions, reducing substance P-mediated inflammation.

[1] Topical capsaicin for chronic pain — Cochrane Database of Systematic Reviews (2010)

📋 How to Use

Use topical capsaicin cream for localized inflammation, or add cayenne to food for systemic anti-inflammatory benefits.

💊 Recommended Dosage

0.025-0.075% capsaicin cream topically 3-4 times daily. Or 1/4 teaspoon cayenne in food daily.

⚠️ Side Effects & Cautions

Burning on application (diminishes with use). Avoid eyes and mucous membranes. Wash hands after applying.

🛒 Where to Buy Cayenne Pepper

Capsaicin HP Cream

★★★★ 4.3 · $8-14

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Other Natural Remedies for Inflammation

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Other Conditions Cayenne Pepper Helps

Back Pain

Capsaicin in cayenne depletes substance P, the neurotransmitter that sends pain signals to the brain...

Joint Pain

Topical capsaicin depletes substance P from nerve endings near the joint, reducing pain signaling. I...

📚 Sources

Topical capsaicin for chronic pain — Cochrane Database of Systematic Reviews (2010)

Last reviewed: February 2026 · Medical disclaimer applies

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